Colonic polyposis

A 30-year-old female, with no significant family history, came with complaints of intermittent, colicky abdominal pain and abdominal distension of 5 months duration, with significant weight loss. CT abdomen showed multiple polypoidal lesions in the colon. Colonoscopy revealed multiple polyps carpeting the entire colon (Fig. 1A); biopsy of which revealed adenomatous polyps. The patient underwent total proctocolectomy with J-pouch ileo-anal anastomosis and ileostomy. Gross examination is depicted in Fig. 1B. Microscopic picture is demonstrated in Fig. 2. Patient is currently doing well on a one-month follow up. Familial adenomatous polyposis (FAP) is an autosomal dominant, inheritable condition, characterized by over a hundred adenomatous polyps in the large intestine. It is linked to mutations of the adenomatous polyposis coli (APC) gene located on chromosome 5q21. Adenomatous polyps are present in nearly 100% by 40 years of age [1]. The lifetime risk of colorectal malignancy in untreated patients with FAP is near 100% with a median age of 39 years [2]. Surgical options include total abdominal colectomy with ileorectostomy, proctocolectomy with ileal pouch anal reconstruction, and total proctocolectomy with Brooke ileostomy [1-3].